DENVER (AP) — The Pepsi Center remains Dwyane Wade’s personal house of horrors.

The Miami Heat star fell to 0-6 in Denver when Carmelo Anthony and Nene led the Nuggets to a 114-96 rout Thursday night.

Denver is the only city where Wade has never won in his seven seasons in the NBA.

Wade, who snapped an 0-11 skid at Indiana earlier this season, had high hopes for another breakthrough against the Nuggets — 96-88 losers last month in Miami.

Despite his 25 points, this one wasn’t close. The Nuggets led by 29 before both coaches emptied their benches early in the fourth quarter.

Anthony, the league’s leading scorer, led the Nuggets with 22 points, and five of his teammates reached double figures, too, including J.R. Smith, who scored all 16 of his points in the first half.

Anthony, the only player in the NBA to score at least 20 points in every game, was stuck at 17 early in the fourth quarter when Aaron Afflalo was seated beneath the scorer’s desk, ready to check in for him. But Anthony sank two free throws and then hit a 3-pointer before the next dead ball, extending his streak.

Despite Wade’s 25 points, his night was epitomized by the 3-pointer he took from the left corner in the third quarter that rang the rim twice and spun out just as it appeared to be falling through the hoop.

Wade also drew a technical foul in the third quarter seconds after his coach was T’d up as the Nuggets were expanding their lead past 25.

Nene scored nine of his 15 points in an 13-0 second-quarter run that broke open a close game, giving the Nuggets a 42-28 lead and ending what was shaping up to be a lethargic night for the Nuggets.

The Heat went five minutes without scoring, and Chauncey Billups and Anthony were on the bench for most of that time.

The Nuggets took a 58-42 halftime lead, and it was more of the same in the second half as the Heat looked nothing like the team that that pounded Portland on Tuesday night to begin their four-game Western swing.

Kenyon Martin scored 12 points before drawing back-to-back technical fouls late in the third quarter and getting ejected by referee Monty McCutchen. Moments earlier, Martin saved his coach, George Karl, from a second technical himself, when he went to the sideline and gave his angry coach a bear hug to keep him from getting tossed.

NOTES: Heat coach Erik Spoelstra said before the game he was glad it was on TNT because the extra timeouts would help his team deal with the altitude. Instead, they ended up making a long night even longer for the Heat. … Wade, who was sidelined in his first trip to Denver as a rookie, has scored an average of 24.6 points in Denver but lost by an average of 13.6. … Of the 23 players who got into the game, Malik Allen was the only one who didn’t score.